Endocrine Abstracts

Retinoid-X-receptor (RXR) and retinoic acid receptor (RAR) are transcription factors; each expresses in α, β and γ isoforms. Whereas RAR plays roles in growth and differentiation, RXR regulates lipids homeostasis. Specifically, RXRβ mediates intracellular control of cholesterol levels. RXR is activated by 9-cis-retinoic acid (9-cis-RA), cervonic acid, docosapentaenoic acid, adrenic acid and arachidonic acid. The present investigation was aimed...